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4NIB

Crystal structure of human insulin mutant B20 D-ala, B23 D-ala

Summary for 4NIB
Entry DOI10.2210/pdb4nib/pdb
DescriptorInsulin A chain, Insulin B chain (3 entities in total)
Functional Keywordshormone
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5845.70
Authors
Menting, J.G.,Lawrence, M.C. (deposition date: 2013-11-05, release date: 2014-08-27, Last modification date: 2023-09-20)
Primary citationMenting, J.G.,Yang, Y.,Chan, S.J.,Phillips, N.B.,Smith, B.J.,Whittaker, J.,Wickramasinghe, N.P.,Whittaker, L.J.,Pandyarajan, V.,Wan, Z.L.,Yadav, S.P.,Carroll, J.M.,Strokes, N.,Roberts, C.T.,Ismail-Beigi, F.,Milewski, W.,Steiner, D.F.,Chauhan, V.S.,Ward, C.W.,Weiss, M.A.,Lawrence, M.C.
Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111:E3395-E3404, 2014
Cited by
PubMed: 25092300
DOI: 10.1073/pnas.1412897111
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation

217705

數據於2024-03-27公開中

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