4NHY

Crystal structure of human OGFOD1, 2-oxoglutarate and iron-dependent oxygenase domain containing 1, in complex with pyridine-2,4-dicarboxylic acid (2,4-PDCA)

Summary for 4NHY

Entry DOI	10.2210/pdb4nhy/pdb
Related	4NHL 4NHM 4NHN 4NHX
Descriptor	2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1, MANGANESE (II) ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	jelly-roll fold, translation, ribosome, double-stranded beta helix, oxygen sensing, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	263162.18
Authors	Horita, S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2013-11-05, release date: 2014-11-19, Last modification date: 2023-09-20)
Primary citation	Horita, S.,Scotti, J.S.,Thinnes, C.,Mottaghi-Taromsari, Y.S.,Thalhammer, A.,Ge, W.,Aik, W.,Loenarz, C.,Schofield, C.J.,McDonough, M.A. Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases. Structure, 23:639-652, 2015 Cited by PubMed: 25728928 DOI: 10.1016/j.str.2015.01.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.603 Å)

Structure validation