4NHY

Crystal structure of human OGFOD1, 2-oxoglutarate and iron-dependent oxygenase domain containing 1, in complex with pyridine-2,4-dicarboxylic acid (2,4-PDCA)

4NHY の概要

• エントリーDOI: 10.2210/pdb4nhy/pdb
• 関連するPDBエントリー: 4NHL 4NHM 4NHN 4NHX
• 分子名称: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1, MANGANESE (II) ION, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: jelly-roll fold, translation, ribosome, double-stranded beta helix, oxygen sensing, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 263162.18

構造登録者

Horita, S.,McDonough, M.A.,Schofield, C.J. (登録日: 2013-11-05, 公開日: 2014-11-19, 最終更新日: 2023-09-20)

• 主引用文献: Horita, S.,Scotti, J.S.,Thinnes, C.,Mottaghi-Taromsari, Y.S.,Thalhammer, A.,Ge, W.,Aik, W.,Loenarz, C.,Schofield, C.J.,McDonough, M.A.; Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases.; Structure, 23:639-652, 2015; PubMed: 25728928; DOI: 10.1016/j.str.2015.01.014

実験手法

X-RAY DIFFRACTION (2.603 Å)