4NHM

Crystal structure of Tpa1p from Saccharomyces cerevisiae, termination and polyadenylation protein 1, in complex with N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)

4NHM の概要

• エントリーDOI: 10.2210/pdb4nhm/pdb
• 関連するPDBエントリー: 4NHK 4NHL 4NHX 4NHY
• 分子名称: PKHD-type hydroxylase TPA1, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, MANGANESE (II) ION, ... (5 entities in total)
• 機能のキーワード: 2-oxoglutarate oxygenase, oxygen sensing, protein synthesis regulation, double-stranded beta helix, jellyroll fold, prolyl hydroxylase, translation, ribosome, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Saccharomyces cerevisiae (Baker's yeast)
• 細胞内の位置: Nucleus : P40032
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 75014.31

構造登録者

Scotti, J.S.,McDonough, M.A.,Schofield, C.J. (登録日: 2013-11-05, 公開日: 2014-11-19, 最終更新日: 2023-09-20)

• 主引用文献: Horita, S.,Scotti, J.S.,Thinnes, C.,Mottaghi-Taromsari, Y.S.,Thalhammer, A.,Ge, W.,Aik, W.,Loenarz, C.,Schofield, C.J.,McDonough, M.A.; Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases.; Structure, 23:639-652, 2015; PubMed: 25728928; DOI: 10.1016/j.str.2015.01.014

実験手法

X-RAY DIFFRACTION (1.9 Å)