4NH1

Crystal structure of a heterotetrameric CK2 holoenzyme complex carrying the Andante-mutation in CK2beta and consistent with proposed models of autoinhibition and trans-autophosphorylation

Summary for 4NH1

Entry DOI	10.2210/pdb4nh1/pdb
Related	1JWH 4DGL
Descriptor	Casein kinase II subunit alpha, Casein kinase II subunit beta, MAGNESIUM ION, ... (7 entities in total)
Functional Keywords	eukaryotic protein kinase fold, phosphotransferase (kinase), phosphorylation, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	131366.78
Authors	Schnitzler, A.,Issinger, O.-G.,Niefind, K. (deposition date: 2013-11-04, release date: 2014-03-12, Last modification date: 2023-11-08)
Primary citation	Schnitzler, A.,Olsen, B.B.,Issinger, O.-G.,Niefind, K. The Protein Kinase CK2(Andante) Holoenzyme Structure Supports Proposed Models of Autoregulation and Trans-Autophosphorylation J.Mol.Biol., 426:1871-1882, 2014 Cited by PubMed: 24594356 DOI: 10.1016/j.jmb.2014.02.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation