4NH1

Crystal structure of a heterotetrameric CK2 holoenzyme complex carrying the Andante-mutation in CK2beta and consistent with proposed models of autoinhibition and trans-autophosphorylation

4NH1 の概要

• エントリーDOI: 10.2210/pdb4nh1/pdb
• 関連するPDBエントリー: 1JWH 4DGL
• 分子名称: Casein kinase II subunit alpha, Casein kinase II subunit beta, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: eukaryotic protein kinase fold, phosphotransferase (kinase), phosphorylation, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 131366.78

構造登録者

Schnitzler, A.,Issinger, O.-G.,Niefind, K. (登録日: 2013-11-04, 公開日: 2014-03-12, 最終更新日: 2023-11-08)

• 主引用文献: Schnitzler, A.,Olsen, B.B.,Issinger, O.-G.,Niefind, K.; The Protein Kinase CK2(Andante) Holoenzyme Structure Supports Proposed Models of Autoregulation and Trans-Autophosphorylation; J.Mol.Biol., 426:1871-1882, 2014; PubMed: 24594356; DOI: 10.1016/j.jmb.2014.02.018

実験手法

X-RAY DIFFRACTION (3.3 Å)