4NEU

X-ray structure of Receptor Interacting Protein 1 (RIP1)kinase domain with a 1-aminoisoquinoline inhibitor

Summary for 4NEU

• Entry DOI: 10.2210/pdb4neu/pdb
• Descriptor: Receptor-interacting serine/threonine-protein kinase 1, MAGNESIUM ION, 1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea, ... (4 entities in total)
• Functional Keywords: kinase, atp binding, phosphorylation, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: Q13546
• Total number of polymer chains: 2
• Total formula weight: 77245.26

Authors

Nolte, R.T.,Ward, P.,kahler, K.M.,Campobasso, N. (deposition date: 2013-10-30, release date: 2013-11-20, Last modification date: 2024-02-28)

• Primary citation: Harris, P.A.,Bandyopadhyay, D.,Berger, S.B.,Campobasso, N.,Capriotti, C.A.,Cox, J.A.,Dare, L.,Finger, J.N.,Hoffman, S.J.,Kahler, K.M.,Lehr, R.,Lich, J.D.,Nagilla, R.,Nolte, R.T.,Ouellette, M.T.,Pao, C.S.,Schaeffer, M.C.,Smallwood, A.,Sun, H.H.,Swift, B.A.,Totoritis, R.D.,Ward, P.,Marquis, R.W.,Bertin, J.,Gough, P.J.; Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.; ACS Med Chem Lett, 4:1238-1243, 2013; PubMed: 24900635; DOI: 10.1021/ml400382p

Experimental method

X-RAY DIFFRACTION (2.57 Å)