4NCR
Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169
Summary for 4NCR
Entry DOI | 10.2210/pdb4ncr/pdb |
Related | 4F4Q 4FDP |
Descriptor | decaprenylphosphoryl-beta-D-ribose oxidase, 2-(4-(cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one, bound form, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total) |
Functional Keywords | decaprenylphosphoryl-beta-d-ribose oxidase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 107676.22 |
Authors | Neres, J.,Pojer, F.,Cole, S.T. (deposition date: 2013-10-25, release date: 2014-02-19, Last modification date: 2023-09-20) |
Primary citation | Makarov, V.,Lechartier, B.,Zhang, M.,Neres, J.,van der Sar, A.M.,Raadsen, S.A.,Hartkoorn, R.C.,Ryabova, O.B.,Vocat, A.,Decosterd, L.A.,Widmer, N.,Buclin, T.,Bitter, W.,Andries, K.,Pojer, F.,Dyson, P.J.,Cole, S.T. Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Mol Med, 6:372-383, 2014 Cited by PubMed: 24500695DOI: 10.1002/emmm.201303575 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.881 Å) |
Structure validation
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