4NB3

Crystal structure of RPA70N in complex with a 3,4 dichlorophenylalanine ATRIP derived peptide

4NB3 の概要

• エントリーDOI: 10.2210/pdb4nb3/pdb
• 分子名称: Replication protein A 70 kDa DNA-binding subunit, 3,4 dichlorophenylalanine ATRIP derived peptide (3 entities in total)
• 機能のキーワード: ob fold, protein-protein interaction, 3, 4 dichlorophenylalanine, peptide binding protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P27694
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 31395.78

構造登録者

Feldkamp, M.D.,Frank, A.O.,Vangamudi, B.,Souza-Fagundes, E.M.,Luzwik, J.W.,Cortez, D.,Olejniczak, O.T.,Waterson, A.G.,Rossanese, O.W.,Fesik, S.W.,Chazin, W.J. (登録日: 2013-10-22, 公開日: 2014-02-26, 最終更新日: 2023-09-20)

• 主引用文献: Frank, A.O.,Vangamudi, B.,Feldkamp, M.D.,Souza-Fagundes, E.M.,Luzwick, J.W.,Cortez, D.,Olejniczak, E.T.,Waterson, A.G.,Rossanese, O.W.,Chazin, W.J.,Fesik, S.W.; Discovery of a Potent Stapled Helix Peptide That Binds to the 70N Domain of Replication Protein A.; J.Med.Chem., 57:2455-2461, 2014; PubMed: 24491171; DOI: 10.1021/jm401730y

実験手法

X-RAY DIFFRACTION (1.35 Å)