4N9D

Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)

4N9D の概要

• エントリーDOI: 10.2210/pdb4n9d/pdb
• 関連するPDBエントリー: 4N9B 4N9C
• 分子名称: Nicotinamide phosphoribosyltransferase, 4-({[(4-tert-butylphenyl)sulfonyl]amino}methyl)-N-(pyridin-3-yl)benzamide, PHOSPHATE ION, ... (5 entities in total)
• 機能のキーワード: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P43490
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115294.16

構造登録者

Dragovich, P.S.,Zhao, G.,Baumeister, T.,Bravo, B.,Giannetti, A.M.,Ho, Y.,Hua, R.,Li, G.,Liang, X.,O'Brien, T.,Skelton, N.J.,Wang, C.,Zhao, Q.,Oh, A.,Wang, W.,Wang, Y.,Xiao, Y.,Yuen, P.,Zak, M.,Zheng, X. (登録日: 2013-10-20, 公開日: 2014-02-19, 最終更新日: 2024-02-28)

• 主引用文献: Dragovich, P.S.,Zhao, G.,Baumeister, T.,Bravo, B.,Giannetti, A.M.,Ho, Y.C.,Hua, R.,Li, G.,Liang, X.,Ma, X.,O'Brien, T.,Oh, A.,Skelton, N.J.,Wang, C.,Wang, W.,Wang, Y.,Xiao, Y.,Yuen, P.W.,Zak, M.,Zhao, Q.,Zheng, X.; Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).; Bioorg.Med.Chem.Lett., 24:954-962, 2014; PubMed: 24433859; DOI: 10.1016/j.bmcl.2013.12.062

実験手法

X-RAY DIFFRACTION (1.701 Å)