4N90

Crystal structure of ternary complex of TRAIL, DR5, and Fab fragment from a DR5 agonist antibody

4N90 の概要

• エントリーDOI: 10.2210/pdb4n90/pdb
• 分子名称: Tumor necrosis factor receptor superfamily member 10B, Tumor necrosis factor ligand superfamily member 10, Fab light chain, ... (5 entities in total)
• 機能のキーワード: dr5, trail, agonist, antibody, cooperation, clustering, apoptosis-immune system complex, apoptosis/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: O14763; Membrane; Single-pass type II membrane protein (Potential): P50591
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 242778.05

構造登録者

Huang, X. (登録日: 2013-10-18, 公開日: 2014-09-03)

• 主引用文献: Graves, J.D.,Kordich, J.J.,Huang, T.H.,Piasecki, J.,Bush, T.L.,Sullivan, T.,Foltz, I.N.,Chang, W.,Douangpanya, H.,Dang, T.,O'Neill, J.W.,Mallari, R.,Zhao, X.,Branstetter, D.G.,Rossi, J.M.,Long, A.M.,Huang, X.,Holland, P.M.; Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity.; Cancer Cell, 26:177-189, 2014; PubMed: 25043603; DOI: 10.1016/j.ccr.2014.04.028

実験手法

X-RAY DIFFRACTION (3.3 Å)