4N8W
cathepsin K - chondroitin sulfate complex
Summary for 4N8W
Entry DOI | 10.2210/pdb4n8w/pdb |
Related | 4N79 |
Descriptor | Cathepsin K, 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid (3 entities in total) |
Functional Keywords | collaginase, glycosaminoglycan, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 1 |
Total formula weight | 24919.63 |
Authors | Aguda, A.H.,Nguyen, N.T.,Bromme, D.,Brayer, G.D. (deposition date: 2013-10-18, release date: 2014-11-26, Last modification date: 2020-07-29) |
Primary citation | Aguda, A.H.,Panwar, P.,Du, X.,Nguyen, N.T.,Brayer, G.D.,Bromme, D. Structural basis of collagen fiber degradation by cathepsin K. Proc.Natl.Acad.Sci.USA, 111:17474-17479, 2014 Cited by PubMed: 25422423DOI: 10.1073/pnas.1414126111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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