4N4W

Structure of the human smoothened receptor in complex with SANT-1.

4N4W の概要

• エントリーDOI: 10.2210/pdb4n4w/pdb
• 関連するPDBエントリー: 4JKV
• 分子名称: Cytochrome b(562),Smoothened homolog, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (E)-N-(4-benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine, ... (8 entities in total)
• 機能のキーワード: human smoothened receptor, antitumor agent, novel protein engineering, gpcr network, membrane protein, psi-biology, structural genomics, gpcr, membrane, transport protein
• 由来する生物種: Shigella flexneri 5 str. 8401; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 55387.42

構造登録者

Wang, C.,Wu, H.,Han, G.W.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (登録日: 2013-10-08, 公開日: 2014-01-22, 最終更新日: 2023-09-20)

• 主引用文献: Wang, C.,Wu, H.,Evron, T.,Vardy, E.,Han, G.W.,Huang, X.P.,Hufeisen, S.J.,Mangano, T.J.,Urban, D.J.,Katritch, V.,Cherezov, V.,Caron, M.G.,Roth, B.L.,Stevens, R.C.; Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.; Nat Commun, 5:4355-4355, 2014; PubMed: 25008467; DOI: 10.1038/ncomms5355

実験手法

X-RAY DIFFRACTION (2.8 Å)