4N0O
Complex structure of Arterivirus nonstructural protein 10 (helicase) with DNA
Summary for 4N0O
Entry DOI | 10.2210/pdb4n0o/pdb |
Related | 4N0N |
Descriptor | Replicase polyprotein 1ab, DNA, ZINC ION, ... (5 entities in total) |
Functional Keywords | arterivirus, helicase, zbd, nsp10, complex, hydrolase-dna complex, hydrolase/dna |
Biological source | Equine arteritis virus (EAV) |
Cellular location | Nsp1 papain-like cysteine proteinase: Host nucleus. Nsp2 cysteine proteinase: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 5-6-7: Host membrane; Multi-pass membrane protein (Potential). 3C-like serine proteinase: Host cytoplasm (Potential). RNA-directed RNA polymerase: Host cytoplasm, host perinuclear region (Potential). Helicase: Host cytoplasm, host perinuclear region (Potential): P19811 |
Total number of polymer chains | 8 |
Total formula weight | 192024.55 |
Authors | |
Primary citation | Deng, Z.,Lehmann, K.C.,Li, X.,Feng, C.,Wang, G.,Zhang, Q.,Qi, X.,Yu, L.,Zhang, X.,Feng, W.,Wu, W.,Gong, P.,Tao, Y.,Posthuma, C.C.,Snijder, E.J.,Gorbalenya, A.E.,Chen, Z. Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Res., 42:3464-3477, 2014 Cited by PubMed: 24369429DOI: 10.1093/nar/gkt1310 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
Download full validation report