4N0O

Complex structure of Arterivirus nonstructural protein 10 (helicase) with DNA

Summary for 4N0O

• Entry DOI: 10.2210/pdb4n0o/pdb
• Related: 4N0N
• Descriptor: Replicase polyprotein 1ab, DNA, ZINC ION, ... (5 entities in total)
• Functional Keywords: arterivirus, helicase, zbd, nsp10, complex, hydrolase-dna complex, hydrolase/dna
• Biological source: Equine arteritis virus (EAV)
• Cellular location: Nsp1 papain-like cysteine proteinase: Host nucleus. Nsp2 cysteine proteinase: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 5-6-7: Host membrane; Multi-pass membrane protein (Potential). 3C-like serine proteinase: Host cytoplasm (Potential). RNA-directed RNA polymerase: Host cytoplasm, host perinuclear region (Potential). Helicase: Host cytoplasm, host perinuclear region (Potential): P19811
• Total number of polymer chains: 8
• Total formula weight: 192024.55

Authors

Deng, Z.,Chen, Z. (deposition date: 2013-10-02, release date: 2014-01-08, Last modification date: 2023-09-20)

• Primary citation: Deng, Z.,Lehmann, K.C.,Li, X.,Feng, C.,Wang, G.,Zhang, Q.,Qi, X.,Yu, L.,Zhang, X.,Feng, W.,Wu, W.,Gong, P.,Tao, Y.,Posthuma, C.C.,Snijder, E.J.,Gorbalenya, A.E.,Chen, Z.; Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.; Nucleic Acids Res., 42:3464-3477, 2014; PubMed: 24369429; DOI: 10.1093/nar/gkt1310

Experimental method

X-RAY DIFFRACTION (2.65 Å)