4N0O

Complex structure of Arterivirus nonstructural protein 10 (helicase) with DNA

4N0O の概要

• エントリーDOI: 10.2210/pdb4n0o/pdb
• 関連するPDBエントリー: 4N0N
• 分子名称: Replicase polyprotein 1ab, DNA, ZINC ION, ... (5 entities in total)
• 機能のキーワード: arterivirus, helicase, zbd, nsp10, complex, hydrolase-dna complex, hydrolase/dna
• 由来する生物種: Equine arteritis virus (EAV)
• 細胞内の位置: Nsp1 papain-like cysteine proteinase: Host nucleus. Nsp2 cysteine proteinase: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 5-6-7: Host membrane; Multi-pass membrane protein (Potential). 3C-like serine proteinase: Host cytoplasm (Potential). RNA-directed RNA polymerase: Host cytoplasm, host perinuclear region (Potential). Helicase: Host cytoplasm, host perinuclear region (Potential): P19811
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 192024.55

構造登録者

Deng, Z.,Chen, Z. (登録日: 2013-10-02, 公開日: 2014-01-08, 最終更新日: 2023-09-20)

• 主引用文献: Deng, Z.,Lehmann, K.C.,Li, X.,Feng, C.,Wang, G.,Zhang, Q.,Qi, X.,Yu, L.,Zhang, X.,Feng, W.,Wu, W.,Gong, P.,Tao, Y.,Posthuma, C.C.,Snijder, E.J.,Gorbalenya, A.E.,Chen, Z.; Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.; Nucleic Acids Res., 42:3464-3477, 2014; PubMed: 24369429; DOI: 10.1093/nar/gkt1310

実験手法

X-RAY DIFFRACTION (2.65 Å)