4N08

Structure of Trypanosoma brucei brucei adenosine kinase (apo)

4N08 の概要

• エントリーDOI: 10.2210/pdb4n08/pdb
• 関連するPDBエントリー: 4N09
• 分子名称: Adenosine kinase (2 entities in total)
• 機能のキーワード: anion hole, adenosine kinase, transferase
• 由来する生物種: Trypanosoma brucei brucei
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38228.60

構造登録者

Timm, J.,Wilson, K.S. (登録日: 2013-10-01, 公開日: 2014-01-15, 最終更新日: 2024-02-28)

主引用文献

Timm, J.,Gonzalez-Pacanowska, D.,Wilson, K.S.
Structures of adenosine kinase from Trypanosoma brucei brucei.
Acta Crystallogr F Struct Biol Commun, 70:34-39, 2014

PubMed Abstract: Trypanosoma brucei is a single-cellular parasite of the genus Kinetoplastida and is the causative agent of African sleeping sickness in humans. Adenosine kinase is a key enzyme in the purine-salvage pathway, phosphorylating adenosine to AMP, and also activates cytotoxic analogues such as cordycepin and Ara-A by their phosphorylation. The structures of T. brucei brucei adenosine kinase (TbAK) in its unliganded open conformation and complexed with adenosine and ADP in the closed conformation are both reported to 2.6 Å resolution. The structures give insight into the binding mode of the substrates and the conformational change induced upon substrate binding. This information can be used to guide the improvement of cytotoxic substrate analogues as potential antitrypanosomal drugs.

PubMed: 24419613
DOI: 10.1107/S2053230X13033621

実験手法

X-RAY DIFFRACTION (2.6 Å)