4MYQ
Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33
Summary for 4MYQ
Entry DOI | 10.2210/pdb4myq/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4B, (4-{[2-(5-chlorothiophen-2-yl)-5-ethyl-6-methylpyrimidin-4-yl]amino}phenyl)acetic acid, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | phosphodiesterase, catalytic, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 43499.95 |
Authors | Fox III, D.,Edwards, T.E. (deposition date: 2013-09-27, release date: 2014-01-01, Last modification date: 2023-09-20) |
Primary citation | Fox, D.,Burgin, A.B.,Gurney, M.E. Structural basis for the design of selective phosphodiesterase 4B inhibitors. Cell Signal, 26:657-663, 2014 Cited by PubMed: 24361374DOI: 10.1016/j.cellsig.2013.12.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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