4MYQ

Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33

4MYQ の概要

• エントリーDOI: 10.2210/pdb4myq/pdb
• 分子名称: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, (4-{[2-(5-chlorothiophen-2-yl)-5-ethyl-6-methylpyrimidin-4-yl]amino}phenyl)acetic acid, MAGNESIUM ION, ... (7 entities in total)
• 機能のキーワード: phosphodiesterase, catalytic, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43499.95

構造登録者

Fox III, D.,Edwards, T.E. (登録日: 2013-09-27, 公開日: 2014-01-01, 最終更新日: 2023-09-20)

• 主引用文献: Fox, D.,Burgin, A.B.,Gurney, M.E.; Structural basis for the design of selective phosphodiesterase 4B inhibitors.; Cell Signal, 26:657-663, 2014; PubMed: 24361374; DOI: 10.1016/j.cellsig.2013.12.003

実験手法

X-RAY DIFFRACTION (1.9 Å)