4MXF

X-ray structure of the adduct between bovine pancreatic ribonuclease and Auoxo6, a dinuclear gold(III) complex with -dioxo bridges linking the two metal centers

4MXF の概要

• エントリーDOI: 10.2210/pdb4mxf/pdb
• 関連するPDBエントリー: 1JVT 1JVU 1JVV 4L55 4LFX
• 分子名称: Ribonuclease pancreatic, GOLD ION (3 entities in total)
• 機能のキーワード: ribonuclease fold, hydrolase, rna
• 由来する生物種: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• 細胞内の位置: Secreted: P61823
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27613.62

構造登録者

Russo Krauss, I.,Vergara, A.,Merlino, A. (登録日: 2013-09-26, 公開日: 2013-12-25, 最終更新日: 2024-11-06)

主引用文献

Messori, L.,Scaletti, F.,Massai, L.,Cinellu, M.A.,Russo Krauss, I.,di Martino, G.,Vergara, A.,Paduano, L.,Merlino, A.
Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(iii) compound.
Metallomics, 6:233-236, 2014

PubMed Abstract: The reaction of Auoxo6, a dinuclear gold(III) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug.

PubMed: 24287583
DOI: 10.1039/c3mt00265a

実験手法

X-RAY DIFFRACTION (2.25 Å)