4MTI

Crystal structure of cIAP1 BIR3 bound to T3258042

4MTI の概要

• エントリーDOI: 10.2210/pdb4mti/pdb
• 関連するPDBエントリー: 4MU7
• 分子名称: Baculoviral IAP repeat-containing protein 2, ZINC ION, (3S,8aR)-2-[(2S)-2-cyclohexyl-2-{[(2S)-2-(methylamino)butanoyl]amino}acetyl]-N-[(4R)-3,4-dihydro-2H-chromen-4-yl]octahydropyrrolo[1,2-a]pyrazine-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: ring-type zinc finger, ligase, apoptosis inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q13490
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27799.89

構造登録者

Snell, G.P.,Dougan, D.R. (登録日: 2013-09-19, 公開日: 2013-12-11, 最終更新日: 2024-02-28)

• 主引用文献: Shiokawa, Z.,Hashimoto, K.,Saito, B.,Oguro, Y.,Sumi, H.,Yabuki, M.,Yoshimatsu, M.,Kosugi, Y.,Debori, Y.,Morishita, N.,Dougan, D.R.,Snell, G.P.,Yoshida, S.,Ishikawa, T.; Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.; Bioorg.Med.Chem., 21:7938-7954, 2013; PubMed: 24169315; DOI: 10.1016/j.bmc.2013.09.067

実験手法

X-RAY DIFFRACTION (2.15 Å)