4MT9
Co-crystal structure of tankyrase 1 with compound 49
Summary for 4MT9
Entry DOI | 10.2210/pdb4mt9/pdb |
Related | 4I9I 4MSG 4MSK |
Descriptor | Tankyrase-1, ZINC ION, N-[trans-4-(4-cyanophenoxy)cyclohexyl]-3-[(4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]propanamide, ... (4 entities in total) |
Functional Keywords | tankyrase, parp, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: O95271 |
Total number of polymer chains | 2 |
Total formula weight | 51110.56 |
Authors | Huang, X. (deposition date: 2013-09-19, release date: 2013-12-25, Last modification date: 2024-02-28) |
Primary citation | Hua, Z.,Bregman, H.,Buchanan, J.L.,Chakka, N.,Guzman-Perez, A.,Gunaydin, H.,Huang, X.,Gu, Y.,Berry, V.,Liu, J.,Teffera, Y.,Huang, L.,Egge, B.,Emkey, R.,Mullady, E.L.,Schneider, S.,Andrews, P.S.,Acquaviva, L.,Dovey, J.,Mishra, A.,Newcomb, J.,Saffran, D.,Serafino, R.,Strathdee, C.A.,Turci, S.M.,Stanton, M.,Wilson, C.,Dimauro, E.F. Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors. J.Med.Chem., 56:10003-10015, 2013 Cited by PubMed: 24294969DOI: 10.1021/jm401317z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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