4MT2

COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE X-RAY CRYSTAL STRUCTURE OF RAT METALLOTHIONEIN-2

「2MT2」から置き換えられました 「1MT2」から置き換えられました

4MT2 の概要

• エントリーDOI: 10.2210/pdb4mt2/pdb
• 分子名称: METALLOTHIONEIN ISOFORM II, CADMIUM ION, ZINC ION, ... (5 entities in total)
• 機能のキーワード: metallothionein
• 由来する生物種: Rattus rattus (black rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 6895.24

構造登録者

Robbins, A.H.,Stout, C.D. (登録日: 1993-02-26, 公開日: 1993-07-15, 最終更新日: 2024-11-20)

主引用文献

Braun, W.,Vasak, M.,Robbins, A.H.,Stout, C.D.,Wagner, G.,Kagi, J.H.,Wuthrich, K.
Comparison of the NMR solution structure and the x-ray crystal structure of rat metallothionein-2.
Proc.Natl.Acad.Sci.USA, 89:10124-10128, 1992

PubMed Abstract: Metallothioneins are small cysteine-rich proteins capable of binding heavy metal ions such as Zn2+ and Cd2+. They are ubiquitous tissue components in higher organisms, which tentatively have been attributed both unspecific protective functions against toxic metal ions and highly specific roles in fundamental zinc-regulated cellular processes. In this paper a detailed comparison of the NMR solution structure [Schultze, P., Wörgötter, E., Braun, W., Wagner, G., Vasák, M., Kägi, J. H. R. & Wüthrich, K. (1988) J. Mol. Biol. 203, 251-268] and a recent x-ray crystal structure [Robbins, A. H., McRee, D. E., Williamson, M., Collett, S. A., Xoung, N. H., Furey, W. F., Wang, B. C. & Stout, C. D. (1991) J. Mol. Biol. 221, 1269-1293] of rat metallothionein-2 shows that the metallothionein structures in crystals and in solution have identical molecular architectures. The structures obtained with both techniques now present a reliable basis for discussions on structure-function correlations in this class of metalloproteins.

PubMed: 1438200
DOI: 10.1073/pnas.89.21.10124

実験手法

X-RAY DIFFRACTION (2 Å)