4MOT
Structure of Streptococcus pneumonia pare in complex with AZ13072886
Summary for 4MOT
Entry DOI | 10.2210/pdb4mot/pdb |
Related | 4EM7 4EMV 4MB9 4MBC |
Descriptor | Topoisomerase IV subunit B, 1-[4-(3-methylbutyl)-5-oxo-6-(pyridin-3-yl)-4,5-dihydro[1,3]thiazolo[5,4-b]pyridin-2-yl]-3-prop-2-en-1-ylurea (3 entities in total) |
Functional Keywords | atp binding, structure-based drug design, antimicrobial, virtual screen, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor |
Biological source | Streptococcus pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 24998.22 |
Authors | Ogg, D.,Boriack-Sjodin, P.A. (deposition date: 2013-09-12, release date: 2013-11-20, Last modification date: 2024-02-28) |
Primary citation | Kale, R.R.,Kale, M.G.,Waterson, D.,Raichurkar, A.,Hameed, S.P.,Manjunatha, M.R.,Kishore Reddy, B.K.,Malolanarasimhan, K.,Shinde, V.,Koushik, K.,Jena, L.K.,Menasinakai, S.,Humnabadkar, V.,Madhavapeddi, P.,Basavarajappa, H.,Sharma, S.,Nandishaiah, R.,Mahesh Kumar, K.N.,Ganguly, S.,Ahuja, V.,Gaonkar, S.,Naveen Kumar, C.N.,Ogg, D.,Boriack-Sjodin, P.A.,Sambandamurthy, V.K.,de Sousa, S.M.,Ghorpade, S.R. Thiazolopyridone ureas as DNA gyrase B inhibitors: Optimization of antitubercular activity and efficacy. Bioorg.Med.Chem.Lett., 24:870-879, 2014 Cited by PubMed: 24405701DOI: 10.1016/j.bmcl.2013.12.080 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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