4MMT

Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1 at pH 9.5

Summary for 4MMT

• Entry DOI: 10.2210/pdb4mmt/pdb
• Related: 4JHW 4MMQ 4MMR 4MMS 4MMU 4MMV
• Descriptor: Fusion glycoprotein F2, Fusion glycoprotein F1 fused with Fibritin trimerization domain (2 entities in total)
• Functional Keywords: fusion, membrane, viral protein, structure-based vaccine design
• Biological source: Human respiratory syncytial virus A2; More
• Cellular location: Virion membrane; Single-pass type I membrane protein: P03420; Virion : P10104
• Total number of polymer chains: 2
• Total formula weight: 54824.56

Authors

Joyce, M.G.,Mclellan, J.S.,Stewart-Jones, G.B.E.,Sastry, M.,Yang, Y.,Graham, B.S.,Kwong, P.D. (deposition date: 2013-09-09, release date: 2013-11-20, Last modification date: 2023-09-20)

• Primary citation: McLellan, J.S.,Chen, M.,Joyce, M.G.,Sastry, M.,Stewart-Jones, G.B.,Yang, Y.,Zhang, B.,Chen, L.,Srivatsan, S.,Zheng, A.,Zhou, T.,Graepel, K.W.,Kumar, A.,Moin, S.,Boyington, J.C.,Chuang, G.Y.,Soto, C.,Baxa, U.,Bakker, A.Q.,Spits, H.,Beaumont, T.,Zheng, Z.,Xia, N.,Ko, S.Y.,Todd, J.P.,Rao, S.,Graham, B.S.,Kwong, P.D.; Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.; Science, 342:592-598, 2013; PubMed: 24179220; DOI: 10.1126/science.1243283

Experimental method

X-RAY DIFFRACTION (3.05 Å)