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4MLO

1.65A resolution structure of ToxT from Vibrio cholerae (P21 Form)

Summary for 4MLO
Entry DOI10.2210/pdb4mlo/pdb
DescriptorTCP pilus virulence regulatory protein, CHLORIDE ION, PALMITOLEIC ACID, ... (4 entities in total)
Functional Keywordstoxt, dna binding, transcription regulator
Biological sourceVibrio cholerae
Total number of polymer chains1
Total formula weight32452.79
Authors
Lovell, S.,Wehmeyer, G.,Battaile, K.P.,Li, J.,Egan, S. (deposition date: 2013-09-06, release date: 2016-04-20, Last modification date: 2023-09-20)
Primary citationLi, J.,Wehmeyer, G.,Lovell, S.,Battaile, K.P.,Egan, S.M.
1.65 angstrom resolution structure of the AraC-family transcriptional activator ToxT from Vibrio cholerae.
Acta Crystallogr F Struct Biol Commun, 72:726-731, 2016
Cited by
PubMed Abstract: ToxT is an AraC-family transcriptional activator protein that controls the expression of key virulence factors in Vibrio cholerae, the causative agent of cholera. ToxT directly activates the expression of the genes that encode the toxin-coregulated pilus and cholera toxin, and also positively auto-regulates its own expression from the tcp promoter. The crystal structure of ToxT has previously been solved at 1.9 Å resolution (PDB entry 3gbg). In this study, a crystal structure of ToxT at 1.65 Å resolution with a similar overall structure to the previously determined structure is reported. However, there are distinct differences between the two structures, particularly in the region that extends from Asp101 to Glu110. This region, which can influence ToxT activity but was disordered in the previous structure, can be traced entirely in the current structure.
PubMed: 27599865
DOI: 10.1107/S2053230X1601298X
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.65 Å)
Structure validation

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数据于2025-06-18公开中

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