4MLH
Human Glucokinase in Complex with a Novel Amino Thiazole Allosteric Activator
Summary for 4MLH
Entry DOI | 10.2210/pdb4mlh/pdb |
Related | 4MLE |
Descriptor | Glucokinase, alpha-D-glucopyranose, 3-(benzyloxy)-5-methyl-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine (3 entities in total) |
Functional Keywords | sugar kinase, allosteric activator, small molecule, transferase-transferase activator complex, transferase/transferase activator |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 51500.55 |
Authors | Voegtli, W.C. (deposition date: 2013-09-06, release date: 2013-09-25, Last modification date: 2024-02-28) |
Primary citation | Hinklin, R.J.,Boyd, S.A.,Chicarelli, M.J.,Condroski, K.R.,Dewolf, W.E.,Lee, P.A.,Lee, W.,Singh, A.,Thomas, L.,Voegtli, W.C.,Williams, L.,Aicher, T.D. Identification of a New Class of Glucokinase Activators through Structure-Based Design. J.Med.Chem., 56:7669-7678, 2013 Cited by PubMed: 24015910DOI: 10.1021/jm401116k PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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