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4MLE

Human Glucokinase in Complex with Novel Amino Thiazole Activator

Summary for 4MLE
Entry DOI10.2210/pdb4mle/pdb
Related4MLH
DescriptorGlucokinase, alpha-D-glucopyranose, 3-(benzyloxy)-N-(4-methyl-1,3-thiazol-2-yl)pyridin-2-amine (3 entities in total)
Functional Keywordssugar kinase, allosteric activator, small molecule, transferase-transferase activator complex, transferase/transferase activator
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight51486.53
Authors
Voegtli, W.C. (deposition date: 2013-09-06, release date: 2013-09-25, Last modification date: 2024-02-28)
Primary citationHinklin, R.J.,Boyd, S.A.,Chicarelli, M.J.,Condroski, K.R.,Dewolf, W.E.,Lee, P.A.,Lee, W.,Singh, A.,Thomas, L.,Voegtli, W.C.,Williams, L.,Aicher, T.D.
Identification of a New Class of Glucokinase Activators through Structure-Based Design.
J.Med.Chem., 56:7669-7678, 2013
Cited by
PubMed: 24015910
DOI: 10.1021/jm401116k
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

数据于2024-03-27公开中

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