4MK8

Hepatitis C Virus polymerase NS5B genotype 1b (BK) in complex with inhibitor 4 (N-(4-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]ethyl}phenyl)methanesulfonamide)

4MK8 の概要

• エントリーDOI: 10.2210/pdb4mk8/pdb
• 関連するPDBエントリー: 4MIA 4MIB 4MK7 4MK9 4MKA 4MKB
• 分子名称: RNA-DIRECTED RNA POLYMERASE, DIMETHYL SULFOXIDE, N-(4-{2-[3-tert-butyl-2-methoxy-5-(2-oxo-1,2-dihydropyridin-3-yl)phenyl]ethyl}phenyl)methanesulfonamide, ... (5 entities in total)
• 機能のキーワード: polymerase, transferase, ns5b, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Hepatitis C virus (HCV)
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 127945.10

構造登録者

Harris, S.F.,Wong, A. (登録日: 2013-09-04, 公開日: 2013-10-09, 最終更新日: 2014-01-15)

• 主引用文献: Schoenfeld, R.C.,Bourdet, D.L.,Brameld, K.A.,Chin, E.,de Vicente, J.,Fung, A.,Harris, S.F.,Lee, E.K.,Le Pogam, S.,Leveque, V.,Li, J.,Lui, A.S.,Najera, I.,Rajyaguru, S.,Sangi, M.,Steiner, S.,Talamas, F.X.,Taygerly, J.P.,Zhao, J.; Discovery of a Novel Series of Potent Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B.; J.Med.Chem., 56:8163-8182, 2013; PubMed: 24069953; DOI: 10.1021/jm401266k

実験手法

X-RAY DIFFRACTION (2.09 Å)