4MJU

Influenza Neuraminidase in complex with a novel antiviral compound

Summary for 4MJU

• Entry DOI: 10.2210/pdb4mju/pdb
• Related: 4MJU
• Descriptor: Neuraminidase, (5R,9R,10S)-10-(acetylamino)-2-amino-4-oxo-9-(pentan-3-yloxy)-1-thia-3-azaspiro[4.5]deca-2,6-diene-7-carboxylic acid, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: sialidase, neuraminidase, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus
• Cellular location: Virion membrane : Q07599
• Total number of polymer chains: 1
• Total formula weight: 43474.92

Authors

Kerry, P.S. (deposition date: 2013-09-04, release date: 2014-01-15, Last modification date: 2023-09-20)

• Primary citation: Mohan, S.,Kerry, P.S.,Bance, N.,Niikura, M.,Pinto, B.M.; Serendipitous discovery of a potent influenza virus a neuraminidase inhibitor.; Angew.Chem.Int.Ed.Engl., 53:1076-1080, 2014; PubMed: 24339250; DOI: 10.1002/anie.201308142

Experimental method

X-RAY DIFFRACTION (2.35 Å)