4MI6

Crystal structure of Gpb in complex with SUGAR (N-[4-(5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)BUTANOYL]-BETA-D-GLUCOPYRANOSYLAMINE)

Summary for 4MI6

Entry DOI	10.2210/pdb4mi6/pdb
Related	4MHO 4MHS 4MI3 4MI9 4MIC
Descriptor	Glycogen phosphorylase, muscle form, N-[4-(5,6,7,8-tetrahydronaphthalen-2-yl)butanoyl]-beta-D-glucopyranosylamine (3 entities in total)
Functional Keywords	alpha and beta protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Total number of polymer chains	1
Total formula weight	95888.48
Authors	Kantsadi, L.A.,Chatzileontiadou, S.M.D.,Leonidas, D.D. (deposition date: 2013-08-30, release date: 2014-07-23, Last modification date: 2023-12-06)
Primary citation	Parmenopoulou, V.,Kantsadi, A.L.,Tsirkone, V.G.,Chatzileontiadou, D.S.,Manta, S.,Zographos, S.E.,Molfeta, C.,Archontis, G.,Agius, L.,Hayes, J.M.,Leonidas, D.D.,Komiotis, D. Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-beta-d-glucopyranosylamines. Bioorg.Med.Chem., 22:4810-4825, 2014 Cited by PubMed: 25092521 DOI: 10.1016/j.bmc.2014.06.058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation