4MI0
Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2)
Summary for 4MI0
Entry DOI | 10.2210/pdb4mi0/pdb |
Descriptor | Histone-lysine N-methyltransferase EZH2, ZINC ION, UNKNOWN ATOM OR ION, ... (4 entities in total) |
Functional Keywords | ezh2, gene regulation, chromatin modification, histone methyltransferase, transcription, gene silencing, polycomb repressive complex 2, structural genomics, structural genomics consortium, sgc, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q15910 |
Total number of polymer chains | 1 |
Total formula weight | 27098.87 |
Authors | Dong, A.,Zeng, H.,He, H.,Wernimont, A.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Wu, H.,Structural Genomics Consortium (SGC) (deposition date: 2013-08-30, release date: 2013-09-25, Last modification date: 2024-02-28) |
Primary citation | Wu, H.,Zeng, H.,Dong, A.,Li, F.,He, H.,Senisterra, G.,Seitova, A.,Duan, S.,Brown, P.J.,Vedadi, M.,Arrowsmith, C.H.,Schapira, M. Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. Plos One, 8:e83737-e83737, 2013 Cited by PubMed: 24367611DOI: 10.1371/journal.pone.0083737 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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