4MHS
Crystal structure of Gpb in complex with SUGAR (N-[(2E)-3-(BIPHENYL-4-YL)PROP-2-ENOYL]-BETA-D-GLUCOPYRANOSYLAMINE
Summary for 4MHS
Entry DOI | 10.2210/pdb4mhs/pdb |
Related | 4MHO 4MI3 4MI6 4MI9 4MIC |
Descriptor | Glycogen phosphorylase, muscle form, N-[(2E)-3-(biphenyl-4-yl)prop-2-enoyl]-beta-D-glucopyranosylamine, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | alpha and beta protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
Total number of polymer chains | 1 |
Total formula weight | 95972.57 |
Authors | Kantsadi, L.A.,Chatzileontiadou, S.M.D.,Leonidas, D.D. (deposition date: 2013-08-30, release date: 2014-07-23, Last modification date: 2023-12-06) |
Primary citation | Parmenopoulou, V.,Kantsadi, A.L.,Tsirkone, V.G.,Chatzileontiadou, D.S.,Manta, S.,Zographos, S.E.,Molfeta, C.,Archontis, G.,Agius, L.,Hayes, J.M.,Leonidas, D.D.,Komiotis, D. Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-beta-d-glucopyranosylamines. Bioorg.Med.Chem., 22:4810-4825, 2014 Cited by PubMed: 25092521DOI: 10.1016/j.bmc.2014.06.058 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report