4MHS

Crystal structure of Gpb in complex with SUGAR (N-[(2E)-3-(BIPHENYL-4-YL)PROP-2-ENOYL]-BETA-D-GLUCOPYRANOSYLAMINE

4MHS の概要

• エントリーDOI: 10.2210/pdb4mhs/pdb
• 関連するPDBエントリー: 4MHO 4MI3 4MI6 4MI9 4MIC
• 分子名称: Glycogen phosphorylase, muscle form, N-[(2E)-3-(biphenyl-4-yl)prop-2-enoyl]-beta-D-glucopyranosylamine, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: alpha and beta protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 95972.57

構造登録者

Kantsadi, L.A.,Chatzileontiadou, S.M.D.,Leonidas, D.D. (登録日: 2013-08-30, 公開日: 2014-07-23, 最終更新日: 2023-12-06)

• 主引用文献: Parmenopoulou, V.,Kantsadi, A.L.,Tsirkone, V.G.,Chatzileontiadou, D.S.,Manta, S.,Zographos, S.E.,Molfeta, C.,Archontis, G.,Agius, L.,Hayes, J.M.,Leonidas, D.D.,Komiotis, D.; Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-beta-d-glucopyranosylamines.; Bioorg.Med.Chem., 22:4810-4825, 2014; PubMed: 25092521; DOI: 10.1016/j.bmc.2014.06.058

実験手法

X-RAY DIFFRACTION (2 Å)