4MGC

Crystal structure of hERa-LBD (Y537S) in complex with benzophenone-2

4MGC の概要

• エントリーDOI: 10.2210/pdb4mgc/pdb
• 関連するPDBエントリー: 3UU7 3UUA 3UUC 3UUD 4MG5 4MG6 4MG7 4MG8 4MG9 4MGA 4MGB 4MGD
• 分子名称: Estrogen receptor, Nuclear receptor coactivator 1, bis(2,4-dihydroxyphenyl)methanone, ... (5 entities in total)
• 機能のキーワード: ligand-binding domain of nuclear hormone receptor, hormone receptor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372; Nucleus : Q15788
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 62217.00

構造登録者

Delfosse, V.,Grimaldi, M.,Bourguet, W. (登録日: 2013-08-28, 公開日: 2014-09-03, 最終更新日: 2023-12-06)

主引用文献

Delfosse, V.,Grimaldi, M.,Cavailles, V.,Balaguer, P.,Bourguet, W.
Structural and functional profiling of environmental ligands for estrogen receptors.
Environ.Health Perspect., 122:1306-1313, 2014

PubMed Abstract: Individuals are exposed daily to environmental pollutants that may act as endocrine-disrupting chemicals (EDCs), causing a range of developmental, reproductive, metabolic, or neoplastic diseases. With their mostly hydrophobic pocket that serves as a docking site for endogenous and exogenous ligands, nuclear receptors (NRs) can be primary targets of small molecule environmental contaminants. However, most of these compounds are chemically unrelated to natural hormones, so their binding modes and associated hormonal activities are hardly predictable.

PubMed: 25260197
DOI: 10.1289/ehp.1408453

実験手法

X-RAY DIFFRACTION (2.15 Å)