4MEO
Crystal Structure of the first bromodomain of human BRD4 in complex with a 2-methyl-quinoline ligand
Summary for 4MEO
Entry DOI | 10.2210/pdb4meo/pdb |
Descriptor | Bromodomain-containing protein 4, 1,2-ETHANEDIOL, N-[3-(2-methyl-1-oxidoquinolin-4-yl)phenyl]acetamide, ... (5 entities in total) |
Functional Keywords | brd4, cap, hunk1, mcap, mitotic chromosome associated protein, brd, small molecule inhibitor, structural genomics consortium, sgc, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15531.91 |
Authors | Filippakopoulos, P.,Picaud, S.,Felletar, I.,Martin, S.,Fedorov, O.,Vidler, L.R.,Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Hoelder, S.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2013-08-27, release date: 2013-09-25, Last modification date: 2023-09-20) |
Primary citation | Vidler, L.R.,Filippakopoulos, P.,Fedorov, O.,Picaud, S.,Martin, S.,Tomsett, M.,Woodward, H.,Brown, N.,Knapp, S.,Hoelder, S. Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening. J.Med.Chem., 56:8073-8088, 2013 Cited by PubMed: 24090311DOI: 10.1021/jm4011302 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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