4MDT

Structure of LpxC bound to the reaction product UDP-(3-O-(R-3-hydroxymyristoyl))-glucosamine

4MDT の概要

• エントリーDOI: 10.2210/pdb4mdt/pdb
• 分子名称: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-glucosamine, ... (5 entities in total)
• 機能のキーワード: deacetylase, hydrolase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 139727.43

構造登録者

Clayton, G.M.,Klein, D.J.,Rickert, K.W.,Patel, S.B.,Kornienko, M.,Zugay-Murphy, J.,Reid, J.C.,Tummala, S.,Sharma, S.,Singh, S.B.,Miesel, L.,Lumb, K.J.,Soisson, S.M. (登録日: 2013-08-23, 公開日: 2013-10-16, 最終更新日: 2023-09-20)

• 主引用文献: Clayton, G.M.,Klein, D.J.,Rickert, K.W.,Patel, S.B.,Kornienko, M.,Zugay-Murphy, J.,Reid, J.C.,Tummala, S.,Sharma, S.,Singh, S.B.,Miesel, L.,Lumb, K.J.,Soisson, S.M.; Structure of the Bacterial Deacetylase LpxC Bound to the Nucleotide Reaction Product Reveals Mechanisms of Oxyanion Stabilization and Proton Transfer.; J.Biol.Chem., 288:34073-34080, 2013; PubMed: 24108127; DOI: 10.1074/jbc.M113.513028

実験手法

X-RAY DIFFRACTION (2.59 Å)