4MDA

Structure of Mos1 transposase catalytic domain and Raltegravir with Mn

4MDA の概要

• エントリーDOI: 10.2210/pdb4mda/pdb
• 関連するPDBエントリー: 2F7T 3HOS 3HOT 4MDB
• 分子名称: Mariner Mos1 transposase, MANGANESE (II) ION, N-(4-fluorobenzyl)-5-hydroxy-1-methyl-2-(1-methyl-1-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}ethyl)-6-oxo-1,6-di hydropyrimidine-4-carboxamide, ... (4 entities in total)
• 機能のキーワード: rnase-h fold, ddd motif, recombinase, dna transposition, dna integration, transposon dna, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Drosophila mauritiana (Fruit fly)
• 細胞内の位置: Nucleus (Probable): Q7JQ07
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27445.85

構造登録者

Richardson, J.M. (登録日: 2013-08-22, 公開日: 2014-01-22, 最終更新日: 2023-09-20)

• 主引用文献: Wolkowicz, U.M.,Morris, E.R.,Robson, M.,Trubitsyna, M.,Richardson, J.M.; Structural Basis of Mos1 Transposase Inhibition by the Anti-retroviral Drug Raltegravir.; Acs Chem.Biol., 9:743-751, 2014; PubMed: 24397848; DOI: 10.1021/cb400791u

実験手法

X-RAY DIFFRACTION (1.7 Å)