4MCC

HinTrmD in complex with N-[4-(AMINOMETHYL)BENZYL]-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE

4MCC の概要

• エントリーDOI: 10.2210/pdb4mcc/pdb
• 関連するPDBエントリー: 4MDB
• 分子名称: tRNA (guanine-N(1)-)-methyltransferase, N-[4-(aminomethyl)benzyl]-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide (3 entities in total)
• 機能のキーワード: trefoil, trmd, sam, sah, sinefungin, hmt, structural genomics, n/a, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Haemophilus influenzae
• 細胞内の位置: Cytoplasm (Potential): P43912
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55786.02

構造登録者

Olivier, N.B.,Hill, P. (登録日: 2013-08-21, 公開日: 2013-09-04, 最終更新日: 2024-02-28)

• 主引用文献: Hill, P.J.,Abibi, A.,Albert, R.,Andrews, B.,Gagnon, M.M.,Gao, N.,Grebe, T.,Hajec, L.I.,Huang, J.,Livchak, S.,Lahiri, S.D.,McKinney, D.C.,Thresher, J.,Wang, H.,Olivier, N.,Buurman, E.T.; Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.; J.Med.Chem., 56:7278-7288, 2013; PubMed: 23981144; DOI: 10.1021/jm400718n

実験手法

X-RAY DIFFRACTION (1.95 Å)