4MCB

H.influenzae TrmD in complex with N-(4-{[(1H-IMIDAZOL-2-YLMETHYL)AMINO]METHYL}BENZYL)-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDINE-5-CARBOXAMIDE

4MCB の概要

• エントリーDOI: 10.2210/pdb4mcb/pdb
• 関連するPDBエントリー: 4MCC
• 分子名称: tRNA (guanine-N(1)-)-methyltransferase, GLYCEROL, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: trefoil, trmd, sam, sah, sinefungin, hmt, structural genomics, trefoil knot, methyl transferase to trna, trna, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Haemophilus influenzae
• 細胞内の位置: Cytoplasm (Potential): P43912
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56289.46

構造登録者

Olivier, N.B.,Hill, P. (登録日: 2013-08-21, 公開日: 2013-09-04, 最終更新日: 2024-02-28)

• 主引用文献: Hill, P.J.,Abibi, A.,Albert, R.,Andrews, B.,Gagnon, M.M.,Gao, N.,Grebe, T.,Hajec, L.I.,Huang, J.,Livchak, S.,Lahiri, S.D.,McKinney, D.C.,Thresher, J.,Wang, H.,Olivier, N.,Buurman, E.T.; Selective Inhibitors of Bacterial t-RNA-(N(1)G37) Methyltransferase (TrmD) That Demonstrate Novel Ordering of the Lid Domain.; J.Med.Chem., 56:7278-7288, 2013; PubMed: 23981144; DOI: 10.1021/jm400718n

実験手法

X-RAY DIFFRACTION (1.94 Å)