4M7Y
Staphylococcus aureus Type II pantothenate kinase in complex with a pantothenate analog
Summary for 4M7Y
Entry DOI | 10.2210/pdb4m7y/pdb |
Related | 4M7X |
Descriptor | Type II pantothenate kinase, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-pentyl-beta-alaninamide, ADENOSINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | pantothenate kinase, inhibitor, antibacterial, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Staphylococcus aureus subsp. aureus |
Cellular location | Cytoplasm : Q8NVG0 |
Total number of polymer chains | 2 |
Total formula weight | 62167.56 |
Authors | Mottaghi, K.,Hong, B.,Tempel, W.,Park, H.,Structural Genomics Consortium (SGC) (deposition date: 2013-08-12, release date: 2014-09-03, Last modification date: 2023-09-20) |
Primary citation | Hughes, S.J.,Barnard, L.,Mottaghi, K.,Tempel, W.,Antoshchenko, T.,Hong, B.S.,Allali-Hassani, A.,Smil, D.,Vedadi, M.,Strauss, E.,Park, H.W. Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product. ACS Infect Dis, 2:627-641, 2016 Cited by PubMed: 27759386DOI: 10.1021/acsinfecdis.6b00090 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report