4M5I

The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

4M5I の概要

• エントリーDOI: 10.2210/pdb4m5i/pdb
• 関連するPDBエントリー: 1HKA 1KBR 1Q0N 4M5G 4M5H 4M5J 4M5K 4M5L 4M5M 4M5N
• 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CALCIUM ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... (6 entities in total)
• 機能のキーワード: folate biosynthesis, diphosphotransferases, pterin, atp binding, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19356.25

構造登録者

Yun, M.,Hoagland, D.,Kumar, G.,Waddell, B.,Rock, C.O.,Lee, R.E.,White, S.W. (登録日: 2013-08-08, 公開日: 2014-04-02, 最終更新日: 2023-09-20)

• 主引用文献: Yun, M.K.,Hoagland, D.,Kumar, G.,Waddell, M.B.,Rock, C.O.,Lee, R.E.,White, S.W.; The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.; Bioorg.Med.Chem., 22:2157-2165, 2014; PubMed: 24613625; DOI: 10.1016/j.bmc.2014.02.022

実験手法

X-RAY DIFFRACTION (1.08 Å)