4M3P

Betaine-Homocysteine S-Methyltransferase from Homo sapiens complexed with Homocysteine

Summary for 4M3P

Entry DOI	10.2210/pdb4m3p/pdb
Related	1LT7 1LT8
Descriptor	Betaine--homocysteine S-methyltransferase 1, ZINC ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	alpha and beta proteins (a/b), tim beta/alpha-barrel, methyltransferase activity, homocysteine s-methyltransferase activity, transferase activity, metal ion binding, betaine-homocysteine s-methyltransferase activity, protein complex binding, betaine, homocysteine, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q93088
Total number of polymer chains	4
Total formula weight	181380.46
Authors	Koutmos, M.,Yamada, K.,Mladkova, J.,Paterova, J.,Diamond, C.E.,Tryon, K.,Jungwirth, P.,Garrow, T.A.,Jiracek, J. (deposition date: 2013-08-06, release date: 2014-06-18, Last modification date: 2024-04-03)
Primary citation	Mladkova, J.,Hladilkova, J.,Diamond, C.E.,Tryon, K.,Yamada, K.,Garrow, T.A.,Jungwirth, P.,Koutmos, M.,Jiracek, J. Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase. Proteins, 82:2552-2564, 2014 Cited by PubMed: 24895213 DOI: 10.1002/prot.24619 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.895 Å)

Structure validation