4M3P
Betaine-Homocysteine S-Methyltransferase from Homo sapiens complexed with Homocysteine
Summary for 4M3P
Entry DOI | 10.2210/pdb4m3p/pdb |
Related | 1LT7 1LT8 |
Descriptor | Betaine--homocysteine S-methyltransferase 1, ZINC ION, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | alpha and beta proteins (a/b), tim beta/alpha-barrel, methyltransferase activity, homocysteine s-methyltransferase activity, transferase activity, metal ion binding, betaine-homocysteine s-methyltransferase activity, protein complex binding, betaine, homocysteine, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q93088 |
Total number of polymer chains | 4 |
Total formula weight | 181380.46 |
Authors | Koutmos, M.,Yamada, K.,Mladkova, J.,Paterova, J.,Diamond, C.E.,Tryon, K.,Jungwirth, P.,Garrow, T.A.,Jiracek, J. (deposition date: 2013-08-06, release date: 2014-06-18, Last modification date: 2024-04-03) |
Primary citation | Mladkova, J.,Hladilkova, J.,Diamond, C.E.,Tryon, K.,Yamada, K.,Garrow, T.A.,Jungwirth, P.,Koutmos, M.,Jiracek, J. Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S-methyltransferase. Proteins, 82:2552-2564, 2014 Cited by PubMed: 24895213DOI: 10.1002/prot.24619 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.895 Å) |
Structure validation
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