4M3M
Influenza Neuraminidase in complex with a stereomutated analogue of Oseltamivir carboxylate
Summary for 4M3M
Entry DOI | 10.2210/pdb4m3m/pdb |
Descriptor | Neuraminidase, (3R,4S,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | sialidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Influenza A virus |
Cellular location | Host apical cell membrane ; Single-pass type II membrane protein : Q0A480 |
Total number of polymer chains | 1 |
Total formula weight | 43668.16 |
Authors | Kerry, P.S. (deposition date: 2013-08-06, release date: 2014-02-12, Last modification date: 2020-07-29) |
Primary citation | Sartori, A.,Dell'amico, L.,Battistini, L.,Curti, C.,Rivara, S.,Pala, D.,Kerry, P.S.,Pelosi, G.,Casiraghi, G.,Rassu, G.,Zanardi, F. Synthesis, structure and inhibitory activity of a stereoisomer of oseltamivir carboxylate. Org.Biomol.Chem., 12:1561-1569, 2014 Cited by PubMed: 24425043DOI: 10.1039/c3ob42069h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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