4M28

UDP-Glucose Pyrophosphorylase from Leishmania major in complex with UTP analog dUpCpp

Summary for 4M28

• Entry DOI: 10.2210/pdb4m28/pdb
• Related: 2OEF 2OEG 4M2A 4M2B
• Descriptor: UDP-glucose pyrophosphorylase, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]uridine (3 entities in total)
• Functional Keywords: udp-glucose pyrophosphorylase, nucleotidyltransferase, rossmann-like alpha/beta/alpha sandwich fold, transferase
• Biological source: Leishmania major
• Total number of polymer chains: 1
• Total formula weight: 56520.94

Authors

Fuehring, J.I.,Routier, F.H.,Lamerz, A.-C.,Baruch, P.,Gerardy-Schahn, R.,Fedorov, R. (deposition date: 2013-08-05, release date: 2014-01-29, Last modification date: 2023-09-20)

• Primary citation: Fuehring, J.I.,Routier, F.H.,Lamerz, A.-C.,Baruch, P.,Gerardy-Schahn, R.,Fedorov, R.; Catalytic mechanism and allosteric regulation of UDP-glucose pyrophosphorylase from Leishmania major; ACS CATALYSIS, 3:2976-2985, 2013; DOI: 10.1021/cs4007777

Experimental method

X-RAY DIFFRACTION (3 Å)