4M18

Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man)

Summary for 4M18

• Entry DOI: 10.2210/pdb4m18/pdb
• Related: 4M17
• Related PRD ID: PRD_900111
• Descriptor: Pulmonary surfactant-associated protein D, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, ... (5 entities in total)
• Functional Keywords: surfactant protein, carbohydrate recognition domain, lectin, sugar binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 12
• Total formula weight: 197832.15

Authors

Goh, B.C.,Rynkiewicz, M.J.,Cafarella, T.R.,White, M.R.,Hartshorn, K.L.,Allen, K.,Crouch, E.C.,Calin, O.,Seeberger, P.H.,Schulten, K.,Seaton, B.A. (deposition date: 2013-08-02, release date: 2013-12-04, Last modification date: 2023-09-20)

• Primary citation: Goh, B.C.,Rynkiewicz, M.J.,Cafarella, T.R.,White, M.R.,Hartshorn, K.L.,Allen, K.,Crouch, E.C.,Calin, O.,Seeberger, P.H.,Schulten, K.,Seaton, B.A.; Molecular mechanisms of inhibition of influenza by surfactant protein d revealed by large-scale molecular dynamics simulation.; Biochemistry, 52:8527-8538, 2013; PubMed: 24224757; DOI: 10.1021/bi4010683

Experimental method

X-RAY DIFFRACTION (3.203 Å)