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4LX1

Crystal structure of Myo5a globular tail domain

4LX1 の概要
エントリーDOI10.2210/pdb4lx1/pdb
関連するPDBエントリー4LWZ 4LX0 4LX2
分子名称Unconventional myosin-Va, SULFATE ION, 1,2-ETHANEDIOL, ... (6 entities in total)
機能のキーワードdil, transport protein
由来する生物種Homo sapiens (human)
タンパク質・核酸の鎖数2
化学式量合計90939.11
構造登録者
Pylypenko, O.,Attanda, W.,Coulibaly, D.,Gauquelin, C.,Houdusse, A. (登録日: 2013-07-29, 公開日: 2013-11-20, 最終更新日: 2023-09-20)
主引用文献Pylypenko, O.,Attanda, W.,Gauquelin, C.,Lahmani, M.,Coulibaly, D.,Baron, B.,Hoos, S.,Titus, M.A.,England, P.,Houdusse, A.M.
Structural basis of myosin V Rab GTPase-dependent cargo recognition.
Proc.Natl.Acad.Sci.USA, 110:20443-20448, 2013
Cited by
PubMed Abstract: Specific recognition of the cargo that molecular motors transport or tether to cytoskeleton tracks allows them to perform precise cellular functions at particular times and positions in cells. However, very little is known about how evolution has favored conservation of functions for some isoforms, while also allowing for the generation of new recognition sites and specialized cellular functions. Here we present several crystal structures of the myosin Va or the myosin Vb globular tail domain (GTD) that gives insights into how the motor is linked to the recycling membrane compartments via Rab11 or to the melanosome membrane via recognition of the melanophilin adaptor that binds to Rab27a. The structures illustrate how the Rab11-binding site has been conserved during evolution and how divergence at another site of the GTD allows more specific interactions such as the specific recognition of melanophilin by the myosin Va isoform. With atomic structural insights, these structures also show how either the partner or the GTD structural plasticity upon association is critical for selective recruitment of the motor.
PubMed: 24248336
DOI: 10.1073/pnas.1314329110
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.87 Å)
構造検証レポート
Validation report summary of 4lx1
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-06-25に公開中

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