4LWF
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ3
Summary for 4LWF
Entry DOI | 10.2210/pdb4lwf/pdb |
Related | 4LWE 4LWG 4LWH 4LWI |
Descriptor | Heat shock protein HSP 90-alpha, 4-(5-amino-1,2-oxazol-3-yl)-6-(propan-2-yl)benzene-1,3-diol (3 entities in total) |
Functional Keywords | rossmann fold, atp binding, molecularchaperone, chaperone |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 23497.65 |
Authors | |
Primary citation | Chen, D.,Shen, A.,Li, J.,Shi, F.,Chen, W.,Ren, J.,Liu, H.,Xu, Y.,Wang, X.,Yang, X.,Sun, Y.,Yang, M.,He, J.,Wang, Y.,Zhang, L.,Huang, M.,Geng, M.,Xiong, B.,Shen, J. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem., 87:765-781, 2014 Cited by PubMed: 25313505DOI: 10.1016/j.ejmech.2014.09.065 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report