4LV2
AmpC beta-lactamase in complex with [1-(6-chloropyrimidin-4-yl)-1H-pyrazol-4-yl] boronic acid
Summary for 4LV2
Entry DOI | 10.2210/pdb4lv2/pdb |
Related | 4LV0 4LV1 4LV3 |
Descriptor | Beta-lactamase, [1-(6-chloropyrimidin-4-yl)-1H-pyrazol-4-yl]boronic acid, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | ampc beta-lactamase, class c, hydrolase, boronic acid, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Escherichia coli |
Cellular location | Periplasm: P00811 |
Total number of polymer chains | 2 |
Total formula weight | 80039.02 |
Authors | London, N.,Eidam, O.,Shoichet, B.K. (deposition date: 2013-07-25, release date: 2014-07-30, Last modification date: 2023-09-20) |
Primary citation | London, N.,Miller, R.M.,Krishnan, S.,Uchida, K.,Irwin, J.J.,Eidam, O.,Gibold, L.,Cimermancic, P.,Bonnet, R.,Shoichet, B.K.,Taunton, J. Covalent docking of large libraries for the discovery of chemical probes. Nat.Chem.Biol., 10:1066-1072, 2014 Cited by PubMed: 25344815DOI: 10.1038/nchembio.1666 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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